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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H 2 S Donor Moiety, in Different Cancer Cell Lines
doi: 10.3390/ijms242216131
Figure Lengend Snippet: Antiproliferative effects of Met ( a ) and Met-ITC ( b ) on MCF-10A breast epithelial cells. Histograms show the cell viability (%) of MCF-10A cells treated with vehicle (DMSO 1%), Met (100 µM–5 mM) or Met-ITC (10 µM–5 mM) for 72 h. Data are expressed as percentages of cell viability with respect to vehicle, set as 100%. Data are shown as mean ± SEM. * indicates the significant difference vs. vehicle (* p < 0.05; ** p < 0.01; *** p < 0.001).
Article Snippet: The non-malignant breast epithelial cell line MCF-10A (Merck KGaA, Darmstadt, Germany) was cultured in a
Techniques:
Journal: International Journal of Molecular Sciences
Article Title: Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H 2 S Donor Moiety, in Different Cancer Cell Lines
doi: 10.3390/ijms242216131
Figure Lengend Snippet: H 2 S release in MCF-10A non-tumorigenic breast epithelial cells. ( a ) Time course of fluorometric recording of H 2 S released by vehicle (DMSO 1%), Met-ITC (10 µM, 100 µM and 1 mM) and reference compound DADS (100 µM) in MCF-10A cells. The increase in intracellular levels of H 2 S is shown as FI. ( b ) Area under the curve (AUC) of the total amount of H 2 S released by vehicle (DMSO 1%), Met-ITC (10 µM, 100 µM and 1 mM) and DADS (100 µM) during 50 min. Data are shown as mean ± SEM. For each cell treatment, no statistical differences were found versus vehicle.
Article Snippet: The non-malignant breast epithelial cell line MCF-10A (Merck KGaA, Darmstadt, Germany) was cultured in a
Techniques: